The subject is the theoretical description of the thermodynamics of nanoscale systems, with a particular focus on quantum effects, the role of information, and the statistical properties of thermodynamic quantities such as work, heat and entropy production. The emphasis will be on gaining fundamental knowledge about non-equilibrium, few-body dynamics, correlations, and fluctuations in nanoscale systems where quantum mechanics plays a key role. Of particular importance will be the analysis of finite-sized thermal reservoirs and their application in engines driven either by heat or by information.